What do first-generation antipsychotics block?

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Multiple Choice

What do first-generation antipsychotics block?

Explanation:
Blockade of dopamine D2 receptors. First-generation antipsychotics exert their effects mainly by antagonizing D2 receptors in the brain, which reduces dopamine signaling in pathways like the mesolimbic tract and helps lessen positive symptoms such as hallucinations and delusions. However, this D2 blockade in other pathways (like nigrostriatal and tuberoinfundibular) leads to side effects such as extrapyramidal symptoms and elevated prolactin. They are not primarily NMDA, GABA-A, or serotonin receptor blockers, which is more characteristic of other drug classes or atypical antipsychotics.

Blockade of dopamine D2 receptors. First-generation antipsychotics exert their effects mainly by antagonizing D2 receptors in the brain, which reduces dopamine signaling in pathways like the mesolimbic tract and helps lessen positive symptoms such as hallucinations and delusions. However, this D2 blockade in other pathways (like nigrostriatal and tuberoinfundibular) leads to side effects such as extrapyramidal symptoms and elevated prolactin. They are not primarily NMDA, GABA-A, or serotonin receptor blockers, which is more characteristic of other drug classes or atypical antipsychotics.

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