Seizures are described as what frequency among the stimulant effects of opioids?

• A. Very Common
• B. Common
• C. Rare
• D. Never

Answer: (C)

Seizures are not a typical consequence of opioid effects; opioids mainly act as CNS depressants, producing analgesia, sedation, and respiratory depression rather than activation or convulsions. When seizures are described in relation to opioids, they’re considered rare events. The exception to this is certain opioids like meperidine, whose metabolite normeperidine can accumulate and lower the seizure threshold in susceptible individuals (for example, with high doses or renal impairment). Outside those uncommon situations, seizures are not a common or expected stimulant-related effect of opioids, so labeling them as rare best fits the general pharmacology.